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Opening statements in the highly anticipated trial of Ghislaine Maxwell begin on Monday in a Manhattan federal court.

Maxwell is being tried on several felony counts, including trafficking underage girls for financier Jeffrey Epstein to sexually abuse.

Here's what you need to know as the trial starts.

What Maxwell is accused of

It's alleged that Maxwell groomed underage girls, offering them lavish trips and gifts in exchange for exploiting them, and that in some cases, she herself participated in the abuse.

Dr. Anthony Fauci, the nation's top infectious disease doctor and the president's chief medical adviser, said on Sunday that it's inevitable that the omicron variant of the coronavirus will be detected in the U.S.

While no cases of the variant have been detected in the U.S. so far, there have been cases detected in Botswana, the United Kingdom, Italy, Germany, Belgium, Israel, the Netherlands, Australia and Hong Kong.

Talks to revive the Iran nuclear deal begin again Monday in Vienna. It'll be the seventh round of meetings between the United States, Iran, European powers and China but the first in nearly six months.

And a lot has happened since the last round to raise the stakes for any deal.

The World Health Organization is convening a special session of its governing body, the World Health Assembly, to start talks on a new global treaty covering pandemics. Representatives of WHO's 194 member states will meet virtually for three days starting on Monday to consider new international rules for handling future outbreaks.

The head of the World Health Organization, Tedros Adhanom Ghebreyesus, says the world has not worked well together to confront the current COVID-19 pandemic.

THE HAGUE, Netherlands — The Netherlands confirmed 13 cases of the new omicron variant of the coronavirus on Sunday and Australia found two as the countries half a world apart became the latest to detect it in travelers arriving from southern Africa.

A raft of curbs being imposed by nations around the world as they scramble to slow the variant's spread also grew, with Israel deciding Sunday to bar entry to foreign nationals in the toughest move so far.

About one in 10 lung transplants in the United States now go to COVID-19 patients, according to data from the United Network for Organ Sharing, or UNOS.

The trend is raising questions about the ethics of allocating a scarce resource to people who have chosen not to be vaccinated against the coronavirus.

"They are accumulating on a steady basis. So it's very much a real thing," says David Klassen, chief medical officer for UNOS.

"If there were more lungs available for transplants, I believe the numbers would be greater than they are," he says.

A colorful cast of characters is on Sunday's ballot for the next president of Honduras.

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Fresh Air Weekend highlights some of the best interviews and reviews from past weeks, and new program elements specially paced for weekends. Our weekend show emphasizes interviews with writers, filmmakers, actors and musicians, and often includes excerpts from live in-studio concerts. This week:

People in Iquitos, Peru, refer to their city as "una isla," an island, even though it's not an island. Iquitos is a port city of roughly 400,000 people on the Amazon River in northeastern Peru. Residents proudly note that it's the largest city in the world that's unreachable by road. You can only get there by boat or by plane.

In the early days of the COVID pandemic being isolated seemed like an advantage. It might delay the arrival of the virus. It might make it easier to contain. But that didn't turn out to be the case for Iquitos.

Updated November 27, 2021 at 12:22 PM ET

The omicron strain of the coronavirus is cropping up across Europe, with cases detected in two people in the United Kingdom, two in Germany and at least one in Italy, as the latest variant of concern spreads around the world.

Rivian and Lucid aren't household names. But, somehow, these two electric startups are each worth more than Ford.

Both companies are flush with cash, and they've reached a major milestone: They are actually producing and delivering vehicles to customers

That has left them at the front of an epic race to recreate Tesla's astonishing success story, as the auto industry speeds toward a transition to electric vehicles.

The production volumes are still small — just a few hundred vehicles each so far. But they have big ambitions to scale up in the coming years.

On a Friday afternoon in early October this year, 8-year-old Maricia Redondo came home from her third grade class in the San Francisco Bay Area with puffy eyes, a runny nose and a cough.

"On Saturday morning we both got tested," says Vanessa Quintero, Maricia's 31-year-old mother. "Our results came back Monday that we were both positive."

Newspaper headline writers joke about keeping "Democrats in Disarray" set in type, just to be ready the next time it's needed.

In any given year or season, that "standing head" pops up about as often as "Weather Snarls Traffic" or "Middle East Peace Talks Collapse."

Holiday shopping season is always high-stakes for Saxon Shoes in Virginia — a time when people shop for several pairs at once and splurge on pricy winter boots.

This year came with extra worries: Would shoppers return after a pandemic freeze? Would Saxon's shoes get snared in the supply chain mess? And then, the question that turned out to be key: Would there be enough workers?

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GHAZIPUR BORDER, New Delhi — Every day for the past year, a sugarcane farmer in a bright-green turban has been chanting prayers inside a bamboo tent erected in the middle of a highway on the Indian capital's outskirts.

Updated November 26, 2021 at 6:18 PM ET

Stephen Sondheim, the Pulitzer Prize- and Tony Award-winning Broadway songwriter has died at age 91. His death occurred early this morning, according to Aaron Meier at DKC O&M, the producers of Company on Broadway.

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MOSCOW (AP) — Russian authorities on Friday released the names of 51 people presumed dead after a devastating methane explosion in a coal mine in Siberia, believed to be the deadliest since 2010.

Updated November 26, 2021 at 3:42 PM ET

The hits just keep coming for an elite team of British archaeologists.

The words "Licorice Pizza" are never spoken in Paul Thomas Anderson's new movie, Licorice Pizza, and so you may wonder where the title comes from, especially if you weren't in Southern California in the '70s. It's the name of an old chain of record stores that were around when Anderson was growing up in the San Fernando Valley.

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